2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140324
    Tetraethyl octane-1,8-diylbis(phosphonate) 5943-61-3
    Tetraethyl octane-1,8-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tetraethyl octane-1,8-diylbis(phosphonate)
  • HY-140852
    Azido-PEG3-methyl ester 2086689-07-6
    Azido-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-methyl ester
  • HY-168309
    7-(Piperidin-4-ylmethyl)-2,7-diazaspiro[3.5]nonane 2894098-26-9
    7-(Piperidin-4-ylmethyl)-2,7-diazaspiro[3.5]nonane is the PROTAC linker of FHD-609 (HY-153367).
    7-(Piperidin-4-ylmethyl)-2,7-diazaspiro[3.5]nonane
  • HY-118411S
    5-Ethynyl-2'-deoxyuridine-13C 1610530-40-9
    5-Ethynyl-2'-deoxyuridine-13C1 (EdU-13C1) is the 13C-labeled 5-Ethynyl-2'-deoxyuridine (HY-118411). 5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5-Ethynyl-2'-deoxyuridine-<sup>13</sup>C
  • HY-132859
    Bromo-C10-OBn 78277-30-2
    Bromo-C10-OBn is a PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-C10-OBn
  • HY-130690
    Propargyl-PEG1-SS-PEG1-C2-Boc 1807518-78-0 98.0%
    Propargyl-PEG1-SS-PEG1-C2-Boc is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-PEG1-C2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG1-SS-PEG1-C2-Boc
  • HY-140750
    Benzyloxy carbonyl-PEG3-C2-Boc 1835759-86-8
    Benzyloxy carbonyl-PEG3-C2-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyloxy carbonyl-PEG3-C2-Boc
  • HY-140450
    Diketone-PEG12-DBCO
    Diketone-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Diketone-PEG12-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Diketone-PEG12-DBCO
  • HY-140769
    Azido-PEG5-succinimidyl carbonate 1402411-88-4
    Azido-PEG5-succinimidyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-succinimidyl carbonate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-succinimidyl carbonate
  • HY-134710
    Benzyl-PEG24-alcohol 2218463-19-3
    Benzyl-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG24-alcohol
  • HY-130897
    Boc-NH-PEG11-CH2CH2N3 2395004-21-2
    Boc-NH-PEG11-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG11-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-NH-PEG11-CH2CH2N3
  • HY-133394
    Azido-PEG7-azide 225523-86-4
    Azido-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-azide
  • HY-140387
    Ms-PEG12-Boc
    Ms-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ms-PEG12-Boc
  • HY-132012
    Benzyl-PEG9-acid
    Benzyl-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG9-acid
  • HY-140156
    Methylamino-PEG4-Boc 1621616-14-5
    Methylamino-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methylamino-PEG4-Boc
  • HY-143844
    Bromo-PEG7-amine
    Bromo-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG7-amine
  • HY-140775
    Azido-PEG1-Boc 1374658-85-1 98.0%
    Azido-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-Boc
  • HY-W096096
    Tetraethylene glycol monohexadecyl ether 5274-63-5
    Tetraethylene glycol monohexadecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tetraethylene glycol monohexadecyl ether
  • HY-147205C
    Biotin-PEG-OH (MW 5000)
    Biotin-PEG-OH (MW 5000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG-OH (MW 5000)
  • HY-141340
    S-acetyl-PEG3-alcohol 153870-20-3
    S-acetyl-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    S-acetyl-PEG3-alcohol
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.